Wednesday, January 9, 2019

Main Components of Liquid Biopsy are Greater than it Seems?: (OAJOM)- Lupine Publishers




Long time ago it was wrongly thought that tumor genes and cells are only existence in the exact tumor site. In spite of the fact of the hypothesis that circulating tumor cells (CTCs) are a fundamental prerequisite to metastasis ( first projected in the 1896 by Thomas Ashworth, an Australian pathologist, ) and the presence of cfDNA report in human plasma by Mandel and Metals in 1948, liquid biopsy were totally ignored till 1977. In 1977, researchers made the novel observation that cancer patients carried cell-free DNA in their peripheral blood which was Initial progress on further of liquid biopsy. Without a doubt, significant progress was not made until recent years with the advent of Next Generation Sequencing (NGS) technology, which significantly improved the sensitivity and specificity of ctDNA detection. Interestingly, research in this field of liquid biopsy has entered a “golden age” in which the huge potential of liquid biopsy main components including CTCs, cfDNA and exosomes make tumor diagnosis and treatment much clearer than before. Liquid biopsy tests are fast traction as a viable substitute to traditional diagnostic tests for cancer. It has the potential to facilitate detect cancer at earlier stages, present a less-expensive and less-invasive way to monitor patients throughout treatment, and can help doctors make better decisions about which drugs are the best fit for personal patients.

https://lupinepublishers.com/cancer-journal/fulltext/main-components-of-liquid-biopsy-are-greater-than-it-seems.ID.000102.php
https://lupinepublishers.com/cancer-journal/abstracts/main-components-of-liquid-biopsy-are-greater-than-it-seems.ID.000102.php
https://lupinepublishers.com/cancer-journal/pdf/OAJOM.MS.ID.000102.pdf


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https://lupinepublishers.com/index.php
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Friday, January 4, 2019

Somatic Mutations in Cancer-Free Individuals: A Liquid Biopsy Connection: (OAJOM)-Lupinepublishers


Somatic Mutations in Cancer-Free Individuals: A Liquid Biopsy Connection By  Chen-Hsiung Yeh in Open Access Journal of Oncologyand Medicine in Lupine Publishers

Somatic mutations have been perceived as the causal event in the origin of the vast majority of cancers. Advanced massively parallel, highthroughput DNA sequencing have enabled the comprehensive characterization of somatic mutations in a large number of tumor samples for precision and personalized therapy. Understanding how these observed genetic alterations give rise to specific cancer phenotypes represents an ultimate goal of cancer genomics. However, somatic mutations are also commonly found in healthy individuals, which interfere with the effectiveness for cancer diagnostics.

https://lupinepublishers.com/cancer-journal/fulltext/somatic-mutations-in-cancer-free-individuals-a-liquid-biopsy-connection.ID.000101.php
https://lupinepublishers.com/cancer-journal/pdf/OAJOM.MS.ID.000101.pdf
https://lupinepublishers.com/cancer-journal/abstracts/somatic-mutations-in-cancer-free-individuals-a-liquid-biopsy-connection.ID.000101.php

For more Lupine Publishers Open Access Journals Please visit our website
https://lupinepublishers.com/index.php
For more Oncology and Medicine articles Please Click


Main Components of Liquid Biopsy are Greater than it Seems?: (OAJOM)- Lupine Publishers

Main Components of Liquid Biopsy are Greater than it Seems? B Seyed Mohammad Tavangar  in   Open Access Journal of Oncologyand Medicin...